This book lost me when Natalie starts seeing a psychology researcher named Alice at the local university. Alice is sure Natalie has experienced a great trauma in her past that could be the key to unlocking why she is able to see two versions of her surroundings. The explanations for the flickering between worlds and time were really confusing and a more than a bit convoluted. In the end, I understood what was going on, but the scenes with Alice were dull and I found myself skimming quite a bit.
Parents need to know that The Love That Split the World is a time-traveling fantasy romance with a strong heroine who's a great role model for adopted kids, especially Native American kids adopted into white families. Smart, strong, and lovingly supported by a family that encourages her to explore her biological heritage, protagonist Natalie will get kids thinking about wanting to fit in. There's a lot of teen drinking, and they're very matter-of-fact about it. Some teens show alcoholic tendencies, and the consequences of driving drunk are shown when one teen ends up in a coma. There's lots of kissing -- the novel is first and foremost a romance -- along with some light making out but no graphic descriptions. Blood's mentioned in a recurring nightmare and on injuries after a couple of fistfights. Many First Nation stories are told; a couple include mentions of murder or a scary skeleton that eats people, and they all provide food for thought about our place in the world and how we learn from hearing our people's stories. The book will encourage teens to think about time travel, multiple universes, our place in the world, love, loyalty, friendship, and more.
The summer before Natalie heads to the Ivy League from her small-town Kentucky home, she's visited by an apparition, Grandmother, who used to visit her frequently during her childhood but who's been absent for the past three years. Grandmother wants to tell her the story of the woman who fell to Earth one more time and then warns Natalie that she only has three months \"to save him.\" Save who Her father or brother Matt, her longtime boyfriend Or Beau, the mesmerizing boy she's never seen before but who seems to know everyone she knows As she tries to piece the puzzle together and to find Grandmother for more answers, her world seems to be literally slipping in and out of time and place. Can THE LOVE THAT SPLIT THE WORLD also put it back together
Families can talk about why so many romances have a fantasy element, especially about moving between worlds, such as in this one. Do they help us understand anything about love in the real world, or are they just a fun escape
Sharp and incisive, Daughter of Deep Silence by bestselling author Carrie Ryan is a deliciously smart revenge thriller that examines perceptions of identity, love, and the lengths to which one girl is willing to go when she thinks she has nothing to lose.
Fans of the novel felt like they were full of all kinds of intense and on edge feelings throughout. The way the novel is written, gives it a poetic feel to it, and readers felt like they wanted to savor each word. The novel makes you think about identity and where certain life choices that you make will take you in life. Even though Henry is billed as young adult, this book is much more than that. It has other elements in it that make it fit in other genres. Some found that she wrote a fresh and gripping work full of lyrical writing that brings to life brand new world that is vivid and visceral.
Fans of the novel found this to be a great read; June was a great character and funny, some found that they were in love with her quickly. Some were captivated by the book by everything: the language, the mythology, and the descriptions. Henry is already a brilliant writer and some hope that she is able to keep it up and produce great novels from here on out. Some found the novel to be beautifully strange, and they loved it so much.
As I tumbled through adolescence - a gawky, freckled tomboy with braces - I looked to Grandfather for that smile that assured me I was the wittiest, most beautiful woman in the world. Behind those warm brown eyes of his lay a reservoir of unconditional love larger than anything I could imagine.
Unconditional love is a love so powerful nothing can alter its activity or purpose. It is so much more than can be contained in the confines of one human life. Yet, it seemed so connected to this one person that I couldn't imagine a world where that special love for me would exist without him.
Easter came on the heels of my grandfather's passing. That year, I felt a special connection to the story recorded in the Bible. I think I understood the depth of the grief the disciples must have felt when the one who had taught them what it was to love and be loved was placed in a grave. I realized how cold and unfeeling the world must have seemed to them, how bereft of all that gave life meaning.
A lot of scholars have wrangled over this exchange, but to me it seems that Jesus was asking Mary not to hold on to his personality as the source of the love she so valued. He was constantly turning his students back to God as our inclusive Parent, as the One who treasures each of us individually and is always with us.
I believe that the unconditional love Mary Magdalene felt in the presence of Jesus had the same source as the unconditional love that sparkled in my grandfather's eyes. It was God's love and God as Love.
I began to realize that love did not disappear from the earth when Jesus continued his spiritual journey and ascended beyond the abilities of his students to see him in the flesh. They found an irrepressible joy that impelled them to share the good news of their Master's words and works. And they felt God - divine Love - present and with them every step of the way.
I was able to sing with gratitude all the rousing hymns that Easter Sunday as the weight of grief slipped off my shoulders. Resurrection was about Life and Love triumphant. My grandfather and I would always be connected by God's love and nothing could ever really separate us. Though I could no longer see him or hold his hand, I realized our love had not diminished but had gotten bigger. We were both discovering that eternal Love was as expansive and inclusive as the universe itself.
The crowd wooed and booed for their favorites and least favorites. \"Love triangle\" received a decent share of jeers, \"paranormal\" split the room, and \"enemies to lovers\" got loud cheers and a \"bingo!\" from the corner of the store.
Entering college at the University of California, Irvine, I brought with me the love of science instilled by my experiences in Science Olympiad and the mentoring of Dr. Sprang. However, I was still unsure which area of science I wanted to pursue. I began my college career convinced that I wanted to major in Biology, but quickly realized that this was not the right fit. As I found myself adrift and trying to formulate a new career plan, I decided to dispatch with the required Organic Chemistry courses, which were almost universally dreaded by my fellow Biology majors. I expected these courses to be difficult and frustrating, but instead found that learning about organic molecules and solving the complex puzzle of multi-step synthesis was fun and gratifying. Around this same time, I decided to begin working towards my honors thesis, which required me to find a lab where I could do research. Considering the amount of fun I had in my Organic Chemistry course, I thought that it would be interesting to experience research in a chemistry lab. I read through all of the faculty research descriptions, and while I was still years away from recognizing an underlying love of supramolecular chemistry, I was immediately drawn to the work of Prof. James Nowick, whose lab was focused on constructing and studying artificial β-sheet structures.
During my Ph.D. studies, I had tremendous fun designing and studying organic foldamers, but I also began to be attracted to the especially privileged molecular recognition and self-assembly properties of nucleic acids. I think that Jeff actually recognized this before I did, as he chose the additional faculty members on my thesis committee to be Profs. Steve Zimmerman and Scott Silverman, who are both leaders in the field of nucleic acid molecular recognition. As my graduation neared, Jeff, Steve, and Scott all enthusiastically encouraged me to pursue postdoctoral research and then a career in academia. After a brief detour into industry while I waited for my husband to finish his Ph.D., I was fortunate to have the opportunity to join the lab of Prof. David Liu at Harvard University. Considering that I had made an early departure from my Biology major as an undergrad, I now found myself working in a chemical biology lab with almost no formal training in molecular or cellular biology. Fortunately, David provided me the freedom to make mistakes and learn from those around me, which allowed me to grow in my knowledge of this field that was almost entirely new to me. Additionally, David and my other former advisors provided me with critical mentoring as I went through the process of applying, interviewing, and negotiating for an academic position. This experience further reinforced to me the value of having great people on your side as you strike out into the world on your own.
In our first attempt to demonstrate this principle of split aptamer ligation, we functionalized one fragment of the cocaine-binding DNA split aptamer  with a cyclooctyne and the other fragment with an azide. Although the cyclooctyne and azide are inherently reactive towards one another , we hypothesized that in the context of the free split aptamer fragments at low concentrations, the second order reaction would be relatively slow; however, addition of cocaine would drive assembly of the DNA strands, placing the two reactants in close proximity to one another and thus dramatically increasing the reaction rate (Figure 2). In our first experiment, we tested the hypothesis that the untemplated second order reaction would be sufficiently slow to prevent accumulation of the background signal. We were surprised to observe significant ligation between the split aptamer fragments, even in the absence of cocaine. While our initial thought was that this background was the result of a second order reaction between the functional groups on the DNA strands, this was quickly disproven, as we found that the untemplated ligation yield was not dependent upon DNA concentration. This led us to take a step back and think more critically about the fundamental principles behind split aptamer assembly. We quickly recognized that the function of split aptamers relies on a thermodynamic balancing act in which the enthalpic gain of base pairing and base stacking in the assembled state is weighed against the entropic cost of assembly. According to this logic, split aptamers will function best when the enthalpy for hybridization between the DNA strands is tuned such that in the absence of the ligand, this enthalpic gain is not quite sufficient to overcome the entropic cost of assembly. This poises the DNA strands at the brink of assembly, where the small amount of additional enthalpy gained through target binding can dramatically shift the equilibrium to favor the assembly of the split aptamer. To test this hypothesis, we carried out a simple experiment in which we measured the ligation yield for the two split aptamer fragments in the absence of cocaine, but in the presence of varying concentrations of sodium chloride, as increasing ionic strength increases the enthalpic gain for nucleic acid duplex formation . We found that the ligation yield consistently increased with increasing ionic strength, which served as an initial validation of our hypothesis regarding the thermodynamics of split aptamer assembly. In the short term, this allowed us to overcome the challenge of background signal by reducing the ionic strength, and we were delighted to observe dose-dependent ligation of the split aptamer fragments with increasing concentrations of cocaine . 59ce067264